🔍 Quick Answer: Rejuran is a skin rejuvenation treatment made from Polynucleotides (PN), highly purified DNA fragments derived from salmon. Unlike traditional Hyaluronic Acid (HA) skin boosters that primarily focus on hydration, Rejuran is designed to support the skin’s natural repair processes, improve skin quality, stimulate collagen production, and enhance overall skin resilience.
Results typically develop gradually over several weeks, making Rejuran a popular choice for individuals concerned with acne scars, fine lines, skin texture, and early signs of aging.
What Is Rejuran? The PN Skin Booster That Repairs Your Skin
If you’ve been searching for a skin booster that does more than just hydrate — one that actually repairs and rebuilds your skin from within — Rejuran might be exactly what you’re looking for. Originally developed in South Korea and now trusted by clinics worldwide, Rejuran has earned its reputation as one of the most clinically supported skin regeneration treatments available today.
What Is Rejuran?
Rejuran is an injectable skin booster produced by PharmaResearch Co., Ltd. in South Korea. Its key ingredient is Polynucleotide (PN) — highly purified DNA fragments derived from wild-caught salmon, processed using patented DNA Optimizing Technology (DOT™).
The PN in Rejuran is highly biocompatible with human tissue and is generally well tolerated by the body when used appropriately. Once injected, It helps support the skin’s natural repair mechanisms, encouraging tissue regeneration and skin rejuvenation.” that tells your skin cells to regenerate, rebuild, and restore themselves.
This makes Rejuran fundamentally different from Hyaluronic Acid (HA) boosters like Restylane or Juvederm, which primarily add moisture. Rejuran goes deeper — repairing the skin’s foundation at the cellular level.
What Are Polynucleotides (PN)?
Polynucleotides are DNA fragments that play an important role in tissue repair and regeneration. In aesthetic medicine, PN is used to help improve skin quality by supporting the skin’s natural healing mechanisms.
Research suggests that Polynucleotides may help:
- Support skin repair and recovery
- Improve skin elasticity
- Enhance collagen production
- Strengthen the skin barrier
- Improve overall skin texture and resilience
For this reason, PN-based treatments have become increasingly popular among individuals seeking long-term skin rejuvenation rather than temporary hydration alone.
How Does Rejuran Work?
After being injected into the dermis, Rejuran supports skin rejuvenation through several mechanisms.
Supporting Skin Repair
Polynucleotides help support the skin’s natural repair processes, which may be beneficial for skin affected by aging, acne scars, environmental stress, or UV exposure.
Supporting Fibroblast Activity
Fibroblasts are specialized skin cells responsible for producing collagen and elastin. Rejuran may help support fibroblast activity, encouraging the production of these important structural proteins.
Improving Skin Quality Over Time
As collagen production gradually increases, many patients notice improvements in skin texture, elasticity, firmness, and overall skin appearance.
The result is healthier-looking skin that continues to improve gradually over time.
Rejuran Healer vs Rejuran I
Rejuran is available in different formulations designed for specific treatment areas.
| Product | Best For |
|---|---|
| Rejuran Healer | Full-face skin rejuvenation, texture improvement, and anti-aging |
| Rejuran I | Delicate eye area, fine lines, dark circles, and crepey skin around the eyes |
Rejuran I — What Makes It Special?
Rejuran I is a specialized formulation designed specifically for the delicate area around the eyes. It has a lower viscosity than standard Rejuran, making it safe and gentle enough for use on thin, sensitive skin around the eye area.
What Rejuran I treats:
- Fine lines and wrinkles around the eyes
- Dark circles caused by thin or damaged skin
- Loss of elasticity in the under-eye area
- Crepey or fragile skin around the eye contour
Because the eye area is one of the first places to show signs of aging, Rejuran I has become one of the most requested treatments at aesthetic clinics across Asia.
Rejuran vs Hyaluronic Acid Skin Boosters
| Feature | Rejuran (PN) | HA Skin Booster |
| Key Ingredient | Polynucleotide (PN) | Hyaluronic Acid (HA) |
| Primary Benefit | Skin repair and regeneration support | Deep hydration |
| Onset of Results | Gradual (4–8 weeks) | Faster (3–7 days) |
| Duration | Approximately 6–12 months* | Approximately 6–9 months* |
| Ideal For | Aging, damaged, or scarred skin | Dry and dehydrated skin |
| Eye Area Option | Yes (Rejuran I) | Limited |
*Results vary depending on individual skin condition and treatment protocol.
Many practitioners recommend combining Rejuran with HA Skin Boosters to achieve both immediate hydration and long-term skin quality improvement.
Can you combine both? Yes — and it’s often recommended. HA boosters provide immediate hydration while Rejuran works on long-term repair. Many doctors combine both for optimal results.
Read more: Types of Skin Booster: Compare 6 Options
Who Is Rejuran Suitable For?
✅ Rejuran may be suitable for individuals who have:
- Acne scars or post-acne skin damage
- Fine lines and early signs of aging
- Thin or fragile skin
- Dull skin with uneven texture
- Reduced skin elasticity
- Dark circles or crepey skin around the eyes
❌ Rejuran is not recommended for:
- Pregnant or breastfeeding women
- People with known allergies to fish or salmon products
- Those with active skin infections or open wounds in the treatment area
A consultation with an experienced physician is recommended to determine whether Rejuran is appropriate for your skin concerns.
What Results Can You Expect?
Rejuran works gradually, which is part of what makes its results look so natural.
| Timeline | What Happens |
|---|---|
| Week 1–2 | Mild redness or small bumps settle down |
| Week 3–4 | Skin texture begins to improve |
| Week 4–8 | Collagen production increases, skin feels firmer |
| Month 3–6 | Full results visible — smoother, more resilient skin |
| Month 6–12 | Results continue, maintenance session recommended |
How Many Sessions Are Needed?
Most doctors recommend a course of 3 sessions, spaced 3–4 weeks apart, for optimal results. After completing the initial course, a maintenance session every 6–12 months helps sustain the improvement.
Aftercare Tips
- Avoid touching or massaging the treated area for 24 hours
- Skip makeup for at least 24 hours post-treatment
- Avoid saunas, steam rooms, and intense exercise for 48 hours
- Apply SPF 50+ sunscreen daily — UV exposure can break down collagen faster
- Stay hydrated to support the skin’s repair process
- Avoid AHA, BHA, or Retinol for the first week
Is Rejuran Skin Booster Safe?
Rejuran has a strong safety profile supported by clinical studies. Rejuran’s purified polynucleotide injectable has benefits including increased skin thickness, wrinkle reduction, and improved skin texture, with only minor adverse events such as local bruising and pain reported.
Common side effects are mild and temporary, including small bumps at injection sites, minor redness, and slight bruising — all of which typically resolve within 24–72 hours.
FAQ : Rejuran Skin Booster
A: A topical numbing cream is applied before treatment, making discomfort minimal. Most patients describe a mild stinging or pressure sensation during injection.
A: Unlike HA boosters, Rejuran results are gradual. Most people notice improvements in skin texture around week 3–4, with full results visible at 2–3 months.
A: Yes. Rejuran pairs well with HA Skin Boosters for hydration, Ulthera or Thermage for lifting, and laser treatments for overall skin quality. Your doctor will advise on the best combination and timing.
A: Rejuran I has a lower viscosity specifically designed for the thin, delicate skin around the eyes. It’s gentler and more precisely formulated for that sensitive area.
A: Rejuran is suitable for most skin types, including sensitive skin. However, people with fish or salmon allergies should avoid it. Always consult a doctor before treatment.
Summary : Rejuran Skin Booster
Rejuran is more than a hydration treatment — it’s a skin repair and regeneration solution backed by clinical evidence. Whether you’re dealing with acne scars, aging skin, or simply want healthier, more resilient skin, Rejuran offers results that go beyond the surface.
For those concerned about the delicate eye area, Rejuran I provides a targeted solution that addresses fine lines, dark circles, and crepey skin with precision and safety.
✨ Interested in Rejuran or Rejuran I at La Grace Clinic? 📞 087 494–4000, 087 494–9000 Line: @lagraceclinic
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